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Another derivative, propionyl- L -carnitine, has been linked to enhanced cardiovascular health and exercise performance, while its effects on gut microbiota and TMAO formation are less well understood [5052]
Notably, RSL3 is widely used as a pharmacological inhibitor of GPX4, although studies in cell-free systems suggest that it may also exhibit inhibitory activity toward thioredoxin reductase 1 (TXNRD1), a key NADPH-dependent antioxidant enzyme that maintains thioredoxin-mediated redox homeostasis
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